High‐Content Analysis of Cancer‐Cell‐Specific Apoptosis and Inhibition of <i>in Vivo</i> Angiogenesis by Synthetic (−)‐Pironetin and Analogs

Abstract excerpt

The natural product (-)-pironetin is a structurally simple small molecule microtubule-perturbing agent whose biological activities appear to be exquisitely dependent on defined stereochemistry and the presence of an eletrophilic alpha,beta-unsaturated lactone moiety. We used alkaloid-catalyzed acyl halide-aldehyde cyclocondensation reactions in asymmetric total syntheses of (-)-pironetin and three synthetic...

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