Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells.

doi:10.1016/j.ejps.2020.105353

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Article

Complexation with β-cyclodextrin enhances apoptosis-mediated cytotoxic effect of harman in chemoresistant BRAF-mutated melanoma cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 1 Jul 2020

Ferraz Christiane Adrielly Alves, de Oliveira Júnior Raimundo Gonçalves, de Oliveira Ana Paula, Groult Hugo, Beaugeard Laureen, Picot Laurent, de Alencar Filho Edilson Beserra, Almeida Jackson Roberto Guedes da Silva, Nunes Xirley Pereira

Abstract excerpt

Harman, a natural β-carboline alkaloid, has recently gained considerable interest due to its anticancer properties. However, its physicochemical characteristics and poor oral bioavailability have been limiting factors for its pharmaceutical development. In this paper, we described the complexation of harman (HAR) with β-cyclodextrin (βCD) as a promising alternative to improve its solubility and consequently its...

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Identifiers

PMID: 32334103
DOI: 10.1016/j.ejps.2020.105353

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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