Article
Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment.
Cancer research - 15 May 2008
Augustine Christina K, Yoshimoto Yasunori, Gupta Mukur, Zipfel Patricia A, Selim M Angelica, Febbo Phillip, Pendergast Ann Marie, Peters William P, Tyler Douglas S
Abstract excerpt
Malignant transformation in melanoma is characterized by a phenotype "switch" from E- to N-cadherin, which is associated with increased motility and invasiveness of the tumor and altered signaling, leading to decreased apoptosis. We hypothesized that the novel pentapeptide (ADH-1), which disrupts N-cadherin adhesion, could sensitize melanoma tumors to the cytotoxic effects of chemotherapy. N-cadherin-expressing...
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