Article
Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids.
Developmental cell - 20 Jul 2010
Kaplan Yosef, Gibbs-Bar Liron, Kalifa Yossi, Feinstein-Rotkopf Yael, Arama Eli
Abstract excerpt
Caspases are executioners of apoptosis but also participate in a variety of vital cellular processes. Here, we identified Soti, an inhibitor of the Cullin-3-based E3 ubiquitin ligase complex required for caspase activation during Drosophila spermatid terminal differentiation (individualization). We further provide evidence that the giant inhibitor of apoptosis-like protein dBruce is a target for the...
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