Article

The C-terminal ZZ domain of the Drosophila ORB2 RNA-binding protein is required for spermatid individualization

2025-08-27

Abstract excerpt

ORB2 is the Drosophila ortholog of the human CPEB2-4 family of RNA-binding proteins, which include a conserved C-terminal Zinc-binding (‘ZZ’) domain. We have recently shown that this domain interacts with several translation co-repressors in the early embryo, and that deletion of this domain from the endogenous orb2 gene results in derepression of its target mRNAs (LOW et al . 2025). Here we assess the effect of...

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Literature Corpus work: 6611fb03-16bc-51dd-8036-1a78a11c8631
DOI: 10.1101/2025.08.22.671863

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