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Karyotypically Normal and Abnormal Human Embryonic Stem Cell Lines Derived from PGD-Analyzed Embryos

3 Apr 2008

Abstract excerpt

Although a normal karyotype is generally a requirement for stem cell lines, new applications are likely to emerge for stem cells with defined chromosomal aneuploidies. We therefore investigated the use of embryos found to be aneuploid on biopsy followed by preimplantation genetic diagnosis (PGD) with fluorescent in situ hybridization (FISH), and developmentally arrested embryos for stem cell derivation. Eleven...

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PMID: 18386991
DOI: 10.1089/clo.2007.0062

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