Article
Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.
Nature genetics - 1 Aug 2010
Conde Lucia, Halperin Eran, Akers Nicholas K, Brown Kevin M, Smedby Karin E, Rothman Nathaniel, Nieters Alexandra, Slager Susan L, Brooks-Wilson Angela, Agana Luz, Riby Jacques, Liu Jianjun, Adami Hans-Olov, Darabi Hatef, Hjalgrim Henrik, Low Hui-Qi, Humphreys Keith, Melbye Mads, Chang Ellen T, Glimelius Bengt, Cozen Wendy, Davis Scott, Hartge Patricia, Morton Lindsay M, Schenk Maryjean, Wang Sophia S, Armstrong Bruce, Kricker Anne, Milliken Sam, Purdue Mark P, Vajdic Claire M, Boyle Peter, Lan Qing, Zahm Shelia H, Zhang Yawei, Zheng Tongzhang, Becker Nikolaus, Benavente Yolanda, Boffetta Paolo, Brennan Paul, Butterbach Katja, Cocco Pierluigi, Foretova Lenka, Maynadié Marc, de Sanjosé Silvia, Staines Anthony, Spinelli John J, Achenbach Sara J, Call Timothy G, Camp Nicola J, Glenn Martha, Caporaso Neil E, Cerhan James R, Cunningham Julie M, Goldin Lynn R, Hanson Curtis A, Kay Neil E, Lanasa Mark C, Leis Jose F, Marti Gerald E, Rabe Kari G, Rassenti Laura Z, Spector Logan G, Strom Sara S, Vachon Celine M, Weinberg J Brice, Holly Elizabeth A, Chanock Stephen, Smith Martyn T, Bracci Paige M, Skibola Christine F
Abstract excerpt
To identify susceptibility loci for non-Hodgkin lymphoma subtypes, we conducted a three-stage genome-wide association study. We identified two variants associated with follicular lymphoma at 6p21.32 (rs10484561, combined P = 1.12 x 10(-29) and rs7755224, combined P = 2.00 x 10(-19); r(2) = 1.0), supporting the idea that major histocompatibility complex genetic variation influences follicular lymphoma...