Article
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
PLoS genetics - 1 Apr 2011
Smedby Karin E, Foo Jia Nee, Skibola Christine F, Darabi Hatef, Conde Lucia, Hjalgrim Henrik, Kumar Vikrant, Chang Ellen T, Rothman Nathaniel, Cerhan James R, Brooks-Wilson Angela R, Rehnberg Emil, Irwan Ishak D, Ryder Lars P, Brown Peter N, Bracci Paige M, Agana Luz, Riby Jacques, Cozen Wendy, Davis Scott, Hartge Patricia, Morton Lindsay M, Severson Richard K, Wang Sophia S, Slager Susan L, Fredericksen Zachary S, Novak Anne J, Kay Neil E, Habermann Thomas M, Armstrong Bruce, Kricker Anne, Milliken Sam, Purdue Mark P, Vajdic Claire M, Boyle Peter, Lan Qing, Zahm Shelia H, Zhang Yawei, Zheng Tongzhang, Leach Stephen, Spinelli John J, Smith Martyn T, Chanock Stephen J, Padyukov Leonid, Alfredsson Lars, Klareskog Lars, Glimelius Bengt, Melbye Mads, Liu Edison T, Adami Hans-Olov, Humphreys Keith, Liu Jianjun
Abstract excerpt
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL...
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