Article
A two-stage evaluation of genetic variation in immune and inflammation genes with risk of non-Hodgkin lymphoma identifies new susceptibility locus in 6p21.3 region.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2012
Cerhan James R, Fredericksen Zachary S, Novak Anne J, Ansell Stephen M, Kay Neil E, Liebow Mark, Dogan Ahmet, Cunningham Julie M, Wang Alice H, Witzig Thomas E, Habermann Thomas M, Asmann Yan W, Slager Susan L
Abstract excerpt
BACKGROUND: Non-Hodgkin lymphoma (NHL) is a malignancy of lymphocytes, and there is growing evidence for a role of germline genetic variation in immune genes in NHL etiology. METHODS: To identify susceptibility immune genes, we conducted a 2-stage analysis of single-nucleotide polymorphisms (SNP) from 1,253 genes using the Immune and Inflammation Panel. In Stage 1, we genotyped 7,670 SNPs in 425 NHL cases and 465...
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