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Article

HLA-linked spinocerebellar ataxia: a clinical and genetic study of large Italian kindreds.

Acta neurologica Scandinavica - 1 Apr 1992

Spadaro M, Giunti P, Lulli P, Frontali M, Jodice C, Cappellacci S, Morellini M, Persichetti F, Trabace S, Anastasi R

Abstract excerpt

Five families with late onset autosomal dominant spinocerebellar ataxia, were studied. Linkage between the disease and HLA loci on the short arm of chromosome 6 was shown in the two largest pedigrees. Clinical study of 26 patients and neuropathological study in one are reported. The disease was characterized by cerebellar and pyramidal involvement variably associated with cranial nerve and peripheral nervous...

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Identifiers

PMID: 1585797
DOI: 10.1111/j.1600-0404.1992.tb04041.x

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