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Article

The Drosophila dorsoventral determinant PIPE contains ten copies of a variable domain homologous to mammalian heparan sulfate 2-sulfotransferase.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2001

Sergeev P, Streit A, Heller A, Steinmann-Zwicky M

Abstract excerpt

In Drosophila, the gene PIPE is expressed in follicle cells, the somatic cells that surround the forming egg during maturation, specifically on one side of the egg chamber. This asymmetry establishes the dorsoventral axis of the future embryo. Through the action of PIPE, the ligand SPATZLE, that is located in the perivitelline fluid of the embryo, is activated ventrally. This signal activates TOLL, a...

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PMID: 11169845
DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1094>3.0.CO;2-A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The Drosophila dorsoventral determinant PIPE contains ten copies of a variable domain homologous to mammalian heparan sulfate 2-sulfotransferase.PMID 11169845Read ↗

Spatially restricted expression of pipe in the Drosophila egg chamber defines embryonic dorsal-ventral polarity.Semantic proximity Read ↗

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Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.Semantic proximity Read ↗

Localized requirements for windbeutel and pipe reveal a dorsoventral prepattern within the follicular epithelium of the Drosophila ovary.Semantic proximity Read ↗

The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal.Semantic proximity Read ↗

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