Article
CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility.
PloS one - 12 Jul 2010
Blanco-Kelly Fiona, Matesanz Fuencisla, Alcina Antonio, Teruel María, Díaz-Gallo Lina M, Gómez-García María, López-Nevot Miguel A, Rodrigo Luis, Nieto Antonio, Cardeña Carlos, Alcain Guillermo, Díaz-Rubio Manuel, de la Concha Emilio G, Fernandez Oscar, Arroyo Rafael, Martín Javier, Urcelay Elena
Abstract excerpt
BACKGROUND: A functional polymorphism located at -1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation. It has been consistently associated with Graves' disease risk in populations of different ethnicity and genetic proxies of this variant evaluated in genome-wide association studies have shown evidence of an effect in rheumatoid...
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