Article
Association of SNPs of CD40 gene with multiple sclerosis in Russians.
PloS one - 1 Jan 2013
Sokolova Ekaterina Alekseevna, Malkova Nadezhda Alekseevna, Korobko Denis Sergeevich, Rozhdestvenskii Aleksey Sergeevich, Kakulya Anastasia Vladimirovna, Khanokh Elena Vladimirovna, Delov Roman Andreevich, Platonov Fedor Alekseevich, Popova Tatyana Yegorovna, Aref' eva Elena Gennadievna, Zagorskaya Natalia Nikolaevna, Alifirova Valentina Mikhailovna, Titova Marina Andreevna, Smagina Inna Vadimovna, El' chaninova Svetlana Alksandrovna, Popovtseva Anna Valentinovna, Puzyrev Valery Pavlovich, Kulakova Olga Georgievna, Tsareva Ekaterina Yur'evna, Favorova Olga Olegovna, Shchur Sergei Gennadievich, Lashch Natalia Yurievna, Popova Natalia Fyodorovna, Popova Ekaterina Valerievna, Gusev Evgenii Ivanovich, Boyko Aleksey Nikolaevich, Aulchenko Yurii Sergeevich, Filipenko Maxim Leonidovich
Abstract excerpt
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected the suggestive association of located upstream of CD40 gene in chromosome 20q13 (p = 1.3×10(-7)). Identification of the causal variant(s) in the CD40 locus leads to a better understanding of the mechanism underlying the development of autoimmune pathologies. We determined the genotypes of rs6074022,...
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