Article
Compelling Evidence Linking CD40 Gene With Graves' Disease in the Chinese Han Population.
Frontiers in endocrinology - 1 Jan 2021
Jiang He, Yuan Fei-Fei, Wang Hai-Ning, Liu Wei, Ye Xiao-Ping, Yang Shao-Ying, Xie Hui-Jun, Yu Sha-Sha, Ma Yu-Ru, Zhang Le-Le, Zhao Shuang-Xia, Song Huai-Dong
Abstract excerpt
Mutations in CD40 have been widely reported to be risk factors for Graves' disease (GD). The gene, along with its cognate ligand CD40L, may regulate pro-inflammatory and immune responses. Rs1883832, located at the -1 position of the Kozak sequence, is the most well-studied single nucleotide polymorphism (SNP) of CD40, and has been confirmed to predispose those with the alteration to GD, regardless of ethnicity....
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