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Article

Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell.

PloS one - 1 Jan 2013

Si Xiaoxing, Chen Wen, Guo Xudong, Chen Long, Wang Guiying, Xu Yanxin, Kang Jiuhong

Abstract excerpt

Sirt2, a member of the NAD(+)-dependent protein deacetylase family, is increasingly recognized as a critical regulator of the cell cycle, cellular necrosis and cytoskeleton organization. However, its role in embryonic stem cells (ESCs) remains unclear. Here we demonstrate that Sirt2 is up-regulat...

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Identifiers

PMID: 24204656
DOI: 10.1371/journal.pone.0076699
PMCID: PMC3800056

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24204656-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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