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Article

MicroRNA Regulation of SIRT1

1 Jan 2012

Abstract excerpt

SIRT1 is an NAD-dependent deacetylase that regulates stress response pathways. By deacetylating transcription factors and co-factors, SIRT1 modulates metabolism, inflammation, hypoxic responses, circadian rhythms, cell survival, and longevity. Since SIRT1 plays a key role in regulating pathways involved in cardiovascular diseases and metabolic diseases cancer, the regulation of SIRT1 has received intense...

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Identifiers

PMID: 22479251
DOI: 10.3389/fphys.2012.00068

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