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Article

Transgenic HFE-dependent induction of hepcidin in mice does not require transferrin receptor-2.

American journal of hematology - 1 Jun 2012

Schmidt Paul J, Fleming Mark D

Abstract excerpt

Hereditary hemochomatosis (HH) is caused by mutations in several genes, including HFE and transferrin receptor-2 (TFR2). Loss of either protein decreases expression of the iron regulatory hormone hepcidin by the liver, leading to inappropriately high iron uptake from the diet, and resulting in systemic iron overload. In tissue culture, overexpressed HFE and TFR2 physically interact. Hepatocellular overexpression...

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Share to Anemia, Hypochromic
Share to Antimicrobial Cationic Peptides
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22460705
DOI: 10.1002/ajh.23173
PMCID: PMC3386558

Genes

HFE
TFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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