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Article

Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1?

The Journal of biological chemistry - 24 Jan 2003

Grewer Christof, Watzke Natalie, Rauen Thomas, Bicho Ana

Abstract excerpt

Glutamate transport by the neuronal excitatory amino acid carrier (EAAC1) is accompanied by the coupled movement of one proton across the membrane. We have demonstrated previously that the cotransported proton binds to the carrier in the absence of glutamate and, thus, modulates the EAAC1 affinity for glutamate. Here, we used site-directed mutagenesis together with a rapid kinetic technique that allows one to...

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PMID: 12419818
DOI: 10.1074/jbc.M207956200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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