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Article

Adaptive strategies of the influenza virus polymerase for replication in humans.

Proceedings of the National Academy of Sciences of the United States of America - 15 Dec 2009

Mehle Andrew, Doudna Jennifer A

Abstract excerpt

Transmission of influenza viruses into the human population requires surmounting barriers to cross-species infection. Changes in the influenza polymerase overcome one such barrier. Viruses isolated from birds generally contain polymerases with the avian-signature glutamic acid at amino acid 627 in the PB2 subunit. These polymerases display restricted activity in human cells. An adaptive change in this residue...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19995968
DOI: 10.1073/pnas.0911915106
PMCID: PMC2789757

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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