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Article

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS.

Proceedings of the National Academy of Sciences of the United States of America - 27 Jul 2010

Ling Shuo-Chien, Albuquerque Claudio P, Han Joo Seok, Lagier-Tourenne Clotilde, Tokunaga Seiya, Zhou Huilin, Cleveland Don W

Abstract excerpt

Dominant mutations in two functionally related DNA/RNA-binding proteins, trans-activating response region (TAR) DNA-binding protein with a molecular mass of 43 KDa (TDP-43) and fused in sarcoma/translocation in liposarcoma (FUS/TLS), cause an inherited form of ALS that is accompanied by nuclear a...

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Identifiers

PMID: 20624952
DOI: 10.1073/pnas.1008227107
PMCID: PMC2922163

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20624952-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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