Features of recent codon evolution: a comparative polymorphism-fixation study.

Abstract excerpt

Features of amino-acid and codon changes can provide us important insights on protein evolution. So far, investigators have often examined mutation patterns at either interspecies fixed substitution or intraspecies nucleotide polymorphism level, but not both. Here, we performed a unique analysis of a combined set of intra-species polymorphisms and inter-species substitutions in human codons. Strong difference in...

Topics

• Amino Acid Substitution
• Animals
• Base Composition
• Codon
• CpG Islands
• Evolution, Molecular
• Humans
• Mice
• Mutation
• Pan troglodytes
• Polymorphism, Genetic
• Species Specificity