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Article

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1.

Carcinogenesis - 1 Sept 2010

Slattery Martha L, Herrick Jennifer S, Lundgreen Abbie, Fitzpatrick Francis A, Curtin Karen, Wolff Roger K

Abstract excerpt

Serine/threonine protein kinase 11 (STK11) and phosphatase tensin homolog deleted on chromosome 10 (PTEN) link insulin sensitivity and metabolic signaling to inflammation and other hormonal factors and colorectal cancer. We evaluate genetic variation in nine genes in a candidate pathway as follow...

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Source

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Identifiers

PMID: 20622004
DOI: 10.1093/carcin/bgq142
PMCID: PMC2930805

Genes

PRKAG2
PTEN
STK11
TSC1
TSC2
PRKAA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20622004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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