Article
Association between functional promoter polymorphisms of macrophage migration inhibitory factor (MIF) gene and ulcerative colitis in Japan.
Cytokine - 1 Aug 2010
Shiroeda Hisakazu, Tahara Tomomitsu, Nakamura Masakatsu, Shibata Tomoyuki, Nomura Tomoe, Yamada Hideto, Hayashi Ranji, Saito Takashi, Yamada Masayoshi, Fukuyama Tomoki, Otsuka Toshimi, Yano Hirokazu, Ozaki Kazuaki, Tsuchishima Mutsumi, Tsutsumi Mikihiro, Arisawa Tomiyasu
Abstract excerpt
Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. Two functional polymorphisms were identified in the promoter region of MIF gene. We attempted to clarify the associations between these polymorphisms and ulcerative colitis (UC). The study was performed in 111 patients with UC and 209 subjects without UC. We employed the PCR-SSCP method to detect gene polymorphisms. Overall, 5/5-CATT...
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