Article
Association of the -173 G/C polymorphism of the macrophage migration inhibitory factor gene with ulcerative colitis.
Journal of gastroenterology - 1 Jan 2004
Nohara Hiroaki, Okayama Naoko, Inoue Nagamu, Koike Yuji, Fujimura Kozue, Suehiro Yutaka, Hamanaka Yuichiro, Higaki Singo, Yanai Hideo, Yoshida Tomoharu, Hibi Toshifumi, Okita Kiwamu, Hinoda Yuji
Abstract excerpt
BACKGROUND: Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in the development of chronic murine colitis. In the +173 G/C polymorphism of the MIF gene, the presence of C creates the binding motif of activator protein 4. This study explored the association of this polymorphism with ulcerative colitis (UC). METHODS: Genotyping was carried out, with a...
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