Article
A single nucleotide variant in microRNA-1269a promotes the occurrence and process of hepatocellular carcinoma by targeting to oncogenes SPATS2L and LRP6.
Bulletin du cancer - 1 Apr 2017
Min Pei, Li Wenshuai, Zeng Deqing, Ma Yanyun, Xu Diannan, Zheng Wanwei, Tang Feng, Chen Jian, Shi Jianping, Hu Heping, Wang Jiucun, Yang Dongqin, Liu Jie, Zhang Jun, Zhang Mingqing
Abstract excerpt
Hepatocellular carcinoma (HCC) is one of the malignant and lethal cancers. Single nucleotide polymorphisms (SNPs) in microRNAs(miRNAs) can affect the expression and target identification of miRNAs and lead to the formation of malignant tumors. However, little is known about whether microRNA-1269a (miR-1269a) SNPs affect the susceptibility and progression of HCC or their specific mechanism. The association between...
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