Article

Evolution of the highest fidelity DNA replication systems

2026-04-17

Abstract excerpt

DNA mutation on average is deleterious, and evolution generally acts to reduce mutation rates to the limit of natural selection. The limit of natural selection is set by multiple factors, of which effective population size is only one. We consider lethal mutagenesis as an upper bound to mutation rates for any organism, an argument that is congruent with a biophysical context, wherein random mutations are a form of...

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Literature Corpus work: 10fa034f-78c0-58ff-867f-9c501a4b5bc4
DOI: 10.64898/2026.04.16.719065

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