Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.

Molecular and cellular biology - 1 Dec 2000

Ledo F, Carrión A M, Link W A, Mellström B, Naranjo J R

Abstract excerpt

Protein kinase A-dependent derepression of the human prodynorphin gene is regulated by the differential occupancy of the Dyn downstream regulatory element (DRE) site. Here, we show that a direct protein-protein interaction between DREAM and the CREM repressor isoform, alphaCREM, prevents binding of DREAM to the DRE and suggests a mechanism for cyclic AMP-dependent derepression of the prodynorphin gene in human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Colforsin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclic AMP-Dependent Protein Kinases

Share to Cyclic AMP Response Element-Binding Protein

Share to Enkephalins

Share to Genes, Regulator

Share to Neuroblastoma

Share to Protein Precursors

Source

Open in PubMed Open full text

Identifiers

PMID: 11094064
DOI: 10.1128/MCB.20.24.9120-9126.2000
PMCID: PMC102170

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.PMID 11094064Read ↗

Ca(2+)-dependent prodynorphin transcriptional derepression in neuroblastoma cells is exerted through DREAM protein activity in a kinase-independent manner.Semantic proximity Read ↗

Protein Kinase A-Dependent Derepression of the Human Prodynorphin Gene via Differential Binding to an Intragenic Silencer ElementSemantic proximity Read ↗

The DREAM-DRE interaction: key nucleotides and dominant negative mutants.Semantic proximity Read ↗

Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM).Semantic proximity Read ↗

Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM.Semantic proximity Read ↗

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.Semantic proximity Read ↗

The central role of CDE/CHR promoter elements in the regulation of cell cycle‐dependent gene transcriptionSemantic proximity Read ↗

Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling.Semantic proximity Read ↗

Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.Semantic proximity Read ↗

URE, an initiator (Inr)-like site, suppresses the promoter of the rat dynorphin gene.Semantic proximity Read ↗

Mitogen-activated protein kinase phosphorylates and targets inducible cAMP early repressor to ubiquitin-mediated destruction.Semantic proximity Read ↗

Cooperative mechanism of transcriptional activation by a cyclic AMP-response element modulator alpha mutant containing a motif for constitutive binding to CREB-binding protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.