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Article

Structural basis for the wobbler mouse neurodegenerative disorder caused by mutation in the Vps54 subunit of the GARP complex.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010

Pérez-Victoria F Javier, Abascal-Palacios Guillermo, Tascón Igor, Kajava Andrey, Magadán Javier G, Pioro Erik P, Bonifacino Juan S, Hierro Aitor

Abstract excerpt

The multisubunit Golgi-associated retrograde protein (GARP) complex is required for tethering and fusion of endosome-derived transport vesicles to the trans-Golgi network. Mutation of leucine-967 to glutamine in the Vps54 subunit of GARP is responsible for spinal muscular atrophy in the wobbler mouse, an animal model of amyotrophic lateral sclerosis. The crystal structure at 1.7 A resolution of the mouse Vps54...

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Identifiers

PMID: 20615984
DOI: 10.1073/pnas.1004756107
PMCID: PMC2919957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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