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Article

VPS54 and the wobbler mouse

21 Oct 2015

Abstract excerpt

The wobbler mouse is an animal model for human motor neuron disease, such as amyotrophic lateral sclerosis (ALS). The spontaneous, recessive wobbler mutation causes degeneration of upper and lower motor neurons leading to progressive muscle weakness with striking similarities to the ALS pathology. The wobbler mutation is a point mutation affecting Vps54, a component of the Golgi-associated retrograde protein...

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PMID: 26539077
DOI: 10.3389/fnins.2015.00381

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