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Article

Salmonella typhimurium prfA mutants defective in release factor 1.

Journal of bacteriology - 1 Jul 1991

Elliott T, Wang X

Abstract excerpt

Mutations have been characterized that map in the prfA gene of Salmonella typhimurium. These weak amber suppressors show increased readthrough of UAG but not UAA or UGA codons. Some hemA mutants exhibit a similar suppressor activity due to transcriptional polarity on prfA. All of the suppressors mapping in prfA are recessive to the wild type. Two mutant prfA genes were cloned onto plasmids, and their DNA...

Topics

Cloning, Molecular
Codon
Escherichia coli
Escherichia coli Proteins
Genes, Bacterial
Genetic Complementation Test
Lac Operon
Multigene Family
Mutation
Peptide Termination Factors
Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella typhimurium

Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2061291
DOI: 10.1128/jb.173.13.4144-4154.1991
PMCID: PMC208064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2061291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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