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Article

The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA.

Molecular and cellular biology - 1 Sept 2010

Kim Dong Hyun, Budhavarapu Varija N, Herrera Carlos R, Nam Hyung Wook, Kim Yu Sam, Yew P Renee

Abstract excerpt

During DNA polymerase switching, the Xenopus laevis Cip/Kip-type cyclin-dependent kinase inhibitor Xic1 associates with trimeric proliferating cell nuclear antigen (PCNA) and is recruited to chromatin, where it is ubiquitinated and degraded. In this study, we show that the predominant E3 for Xic1 in the egg is the Cul4-DDB1-XCdt2 (Xenopus Cdt2) (CRL4(Cdt2)) ubiquitin ligase. The addition of full-length XCdt2 to...

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Share to Cyclin-Dependent Kinase Inhibitor p21
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed DNA Polymerase

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Source

Open in PubMed Open full text

Identifiers

PMID: 20606006
DOI: 10.1128/MCB.01135-09
PMCID: PMC2937564

Genes

PCNA
PIP
DDB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA.PMID 20606006Read ↗

Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.Semantic proximity Read ↗

Ubiquitination of cyclin-dependent kinase inhibitor, Xic1, is mediated by the Xenopus F-box protein xSkp2.Semantic proximity Read ↗

CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1Cdt2 pathway during S phase and after UV irradiation.Semantic proximity Read ↗

CRL4<sup>Cdt2</sup>Semantic proximity Read ↗

An Evolutionarily Conserved Function of Proliferating Cell Nuclear Antigen for Cdt1 Degradation by the Cul4-Ddb1 Ubiquitin Ligase in Response to DNA DamageSemantic proximity Read ↗

Cyclin-dependent kinases phosphorylate human Cdt1 and induce its degradation.Semantic proximity Read ↗

CRL4Cdt2 E3 ubiquitin ligase and proliferating cell nuclear antigen (PCNA) cooperate to degrade thymine DNA glycosylase in S phase.Semantic proximity Read ↗

PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication StressSemantic proximity Read ↗

Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4Cdt2 for PCNA and its ubiquitination activity in S phase.Semantic proximity Read ↗

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase.Semantic proximity Read ↗

Cell type-dependent requirement for PIP box-regulated Cdt1 destruction during S phase.Semantic proximity Read ↗

Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.Semantic proximity Read ↗

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