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Article

Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2010

Souza Renan P, Remington Gary, Chowdhury Nabilah I, Lau Matthew K, Voineskos Aristotle N, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L

Abstract excerpt

There is solid evidence of a genetic predisposition to tardive dyskinesia (TD) although the pathophysiological mechanisms of TD are still unclear. Nevertheless, the dopamine overactivity hypothesis of the TD etiology receives support from both pharmacological and physiological evidence. Dopaminergic signaling modulates the glycogen synthase kinase 3B (GSK-3B), a kinase that may play a critical role in the...

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Identifiers

PMID: 20605420
DOI: 10.1016/j.euroneuro.2010.05.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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