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Article

Glial cell line-derived neurotrophic factor receptor alpha 2 (GFRA2) gene is associated with tardive dyskinesia.

Psychopharmacology - 1 Jun 2010

Souza Renan P, de Luca Vincenzo, Remington Gary, Lieberman Jeffrey A, Meltzer Herbert Y, Kennedy James L, Wong Albert H C

Abstract excerpt

INTRODUCTION: Tardive dyskinesia (TD) has a pharmacogenetic component in which the interaction of antipsychotic exposure with individual genetic variation mediates risk. The glial cell line-derived neurotrophic factor (GDNF) signalling pathway has been associated with neuroprotective effects in central dopaminergic neurons and spinal motor neurons. Clinical trials have also investigated whether GDNF may...

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Source

Identifiers

PMID: 20369355
DOI: 10.1007/s00213-010-1829-4

Genes

GDNF
GFRA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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