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Article

Long-term human growth hormone expression and partial phenotypic correction by plasmid-based gene therapy in an animal model of isolated growth hormone deficiency.

The journal of gene medicine - 1 Jul 2010

Oliveira Nélio A J, Cecchi Cláudia R, Higuti Eliza, Oliveira João E, Jensen Thomas G, Bartolini Paolo, Peroni Cibele N

Abstract excerpt

BACKGROUND: A model for in vivo gene therapy based on electroporation of human growth hormone (hGH)-coding naked DNA in the muscle of dwarf (lit/lit) and immunodeficient dwarf (lit/scid) mice is described. METHODS: A plasmid containing the ubiquitin C promoter and the genomic hGH sequence was administered to the exposed quadriceps muscle, followed by electrotransfer using eight 50-V pulses of 20 ms at a 0.5-s...

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Source

Identifiers

PMID: 20603861
DOI: 10.1002/jgm.1470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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