Article
Partial correction of the dwarf phenotype by non-viral transfer of the growth hormone gene in mice: Treatment age is critical.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Feb 2016
Higuti Eliza, Cecchi Cláudia R, Oliveira Nélio A J, Lima Eliana R, Vieira Daniel P, Aagaard Lars, Jensen Thomas G, Jorge Alexander A L, Bartolini Paolo, Peroni Cibele N
Abstract excerpt
Non-viral transfer of the growth hormone gene to different muscles of immunodeficient dwarf (lit/scid) mice is under study with the objective of improving phenotypic correction via this particular gene therapy approach. Plasmid DNA was administered into the exposed quadriceps or non-exposed tibialis cranialis muscle of lit/scid mice followed by electroporation, monitoring several growth parameters. In a 6-month...
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