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Article

Tetracycline-regulated secretion of human insulin in transfected primary myoblasts.

Biochemical and biophysical research communications - 25 Apr 2003

Scougall Kathleen T, Shaw James A M

Abstract excerpt

A mechanism for safely regulating transgene expression will be necessary for gene therapy approaches to endocrine disorders. In this study, a two-plasmid tetracycline-inducible system was used to regulate expression of human proinsulin (hppI1) and a mutated proinsulin construct (hppI4, allowing cleavage by furin) in primary rat soleus myoblasts. In hppI1 and hppI4 transient transfections, the presence of 0.01 and...

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Identifiers

PMID: 12705902
DOI: 10.1016/s0006-291x(03)00553-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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