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Article

Sustained Expression of Naked Plasmid Dna Encoding Hepatocyte Growth Factor in Mice Promotes Liver and Overall Body Growth

1 Apr 2001

Abstract excerpt

To understand the physiological functions of exogenous hepatocyte growth factor (HGF) on normal adult animals, we delivered human HGF gene into mice by a hydrodynamics-based in vivo gene transfection approach using a naked plasmid vector. Systemic administration of naked plasmid containing HGF cDNA driven under cytomegalovirus promoter (pCMV-HGF) by rapid injection via the tail vein produced a remarkable level of...

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PMID: 11283849
DOI: 10.1053/jhep.2001.23438

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