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Article

The catch bond mechanism between von Willebrand factor and platelet surface receptors investigated by molecular dynamics simulations.

Proteins - 15 Aug 2010

Interlandi Gianluca, Thomas Wendy

Abstract excerpt

The multi-domain protein von Willebrand factor is crucial in the blood coagulation process at high shear. The A1 domain binds to the platelet surface receptor glycoprotein Ibalpha (GpIb alpha) and this interaction is known to be strengthened by tensile force. The molecular mechanism behind this observation was investigated here by molecular dynamics simulations. The results suggest that the proteins unbind...

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Identifiers

PMID: 20602356
DOI: 10.1002/prot.22759
PMCID: PMC6107302

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The catch bond mechanism between von Willebrand factor and platelet surface receptors investigated by molecular dynamics simulations.PMID 20602356Read ↗

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Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.Semantic proximity Read ↗

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