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Article

Promoter region sequence differences in the A and G gamma globin genes of Brazilian sickle cell anemia patients.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Aug 2010

Barbosa C G, Goncalves-Santos N J, Souza-Ribeiro S B, Moura-Neto J P, Takahashi D, Silva D O, Hurtado-Guerrero A F, Reis M G, Goncalves M S

Abstract excerpt

Fetal hemoglobin (HbF), encoded by the HBG2 and HBG1 genes, is the best-known genetic modulator of sickle cell anemia, varying dramatically in concentration in the blood of these patients. This variation is partially associated with polymorphisms located in the promoter region of the HBG2 and HBG1 genes. In order to explore known and unknown polymorphisms in these genes, the sequences of their promoter regions...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20602015
DOI: 10.1590/s0100-879x2010007500062

Genes

HBG2
HBG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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