The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients.

doi:10.1016/j.bcmd.2010.04.002

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Article

The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients.

Blood cells, molecules & diseases - 15 Aug 2010

Nguyen Thi Khanh Tien, Joly Philippe, Bardel Claire, Moulsma Mustapha, Bonello-Palot Nathalie, Francina Alain

Abstract excerpt

The HbF level is a quantitative trait influenced by many loci inside or outside the beta-globin gene cluster. The aim of this study was to analyze in 57 beta-thalassemia intermedia patients with very various genotypes the effects on fetal hemoglobin levels of SNPs lying in three genes or chromosome regions which include the XmnI (G)gamma polymorphism at position -158 of the HBG2 promoter (rs7482144), two SNPs...

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PMID: 20472475
DOI: 10.1016/j.bcmd.2010.04.002

Genes

MYB
HBG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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