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Article

Fetal hemoglobin regulating genetic variants identified in homozygous (HbSS) and heterozygous (HbSA) subjects from South Mexico.

Journal of tropical pediatrics - 4 Aug 2022

Rizo-de la Torre L C, Borrayo-López F J, Perea-Díaz F J, Aquino E, Venegas M, Hernández-Carbajal C, Espinoza-Mata L L, Ibarra-Cortés B

Abstract excerpt

Hemoglobin S is caused by a nucleotide change in HBB gene (HBB:c.20A>T, p.Glu6Val), is presented in diverse forms: simple carriers (HbSA), homozygotes (HbSS) also known as sickle cell anemia, and compound heterozygotes with other β-hemoglobinopathies. It is worldwide distributed, in Mexico, is frequently observed in the southern states Guerrero, Oaxaca and Chiapas. Elevated fetal hemoglobin (HbF) is associated...

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PMID: 36130307
DOI: 10.1093/tropej/fmac073

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