Article
Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D.
American journal of physiology. Lung cellular and molecular physiology - 1 Sept 2010
Hartshorn Kevan L, White Mitchell R, Rynkiewicz Michael, Sorensen Grith, Holmskov Uffe, Head James, Crouch Erika C
Abstract excerpt
Surfactant protein D (SP-D) plays important roles in host defense against a variety of pathogens including influenza A virus (IAV). Ligand binding by SP-D is mediated by the trimeric neck and carbohydrate recognition domain (NCRD). We used monoclonal antibodies (mAbs) against human SP-D and a panel of mutant collectin NCRD constructs to identify functionally and structurally important epitopes. The ability of...
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