Epitope mapping for monoclonal antibodies identifies functional domains of pulmonary surfactant protein A that interact with lipids.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Epitope mapping for monoclonal antibodies identifies functional domains of pulmonary surfactant protein A that interact with lipids.

The Journal of biological chemistry - 25 Nov 1994

Kuroki Y, McCormack F X, Ogasawara Y, Mason R J, Voelker D R

Abstract excerpt

Pulmonary surfactant protein A (SP-A) contains 4 domains: a disulfide forming amino terminus, a collagen-like region, a neck region, and a carbohydrate recognition region. The protein binds the lipids dipalmitoylphosphatidylcholine and galactosylceramide and induces aggregation of phospholipid vesicles. SP-A also inhibits lipid secretion and enhances the uptake of phospholipid by alveolar type II cells....

Topics

Amino Acid Sequence
Animals
Antibodies, Monoclonal
Baculoviridae
Epitopes
Lipid Metabolism
Liposomes
Molecular Sequence Data
Mutation
Proteolipids
Pulmonary Alveoli

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pulmonary Surfactant-Associated Protein A

Pulmonary Surfactant-Associated Proteins

Pulmonary Surfactants

Rats

Rats, Sprague-Dawley

Spodoptera

Source

Open in PubMed

Identifiers

PMID: 7525589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7525589-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epitope mapping for monoclonal antibodies identifies functional domains of pulmonary surfactant protein A that interact with lipids.PMID 7525589Read ↗

Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D.Semantic proximity Read ↗

Mutations of rat surfactant protein A have distinct effects on its glycosylation, secretion, aggregation and degradation.Semantic proximity Read ↗

Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide.Semantic proximity Read ↗

Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses.Semantic proximity Read ↗

Ligand specificity of human surfactant protein D: expression of a mutant trimeric collectin that shows enhanced interactions with influenza A virus.Semantic proximity Read ↗

Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses.Semantic proximity Read ↗

Surfactant protein A without the interruption of Gly-X-Y repeats loses a kink of oligomeric structure and exhibits impaired phospholipid liposome aggregation ability.Semantic proximity Read ↗

Surfactant protein-D and pulmonary host defense.Semantic proximity Read ↗

Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional ActivitySemantic proximity Read ↗

Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen 1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11aSemantic proximity Read ↗

Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction.Semantic proximity Read ↗

Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.