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Article

Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses.

The Journal of biological chemistry - 10 Jun 2011

van Eijk Martin, Bruinsma Laurie, Hartshorn Kevan L, White Mitchell R, Rynkiewicz Michael J, Seaton Barbara A, Hemrika Wieger, Romijn Roland A, van Balkom Bas W, Haagsman Henk P

Abstract excerpt

Porcine surfactant protein D (pSP-D) displays distinctively strong, broad-range inhibitory activity against influenza A virus (IAV). N-Linked glycosylation of the carbohydrate recognition domain (CRD) of pSP-D contributes to the high affinity of this collectin for IAV. To investigate the role of the N-linked glycan further, HEK293E protein expression was used to produce recombinant pSP-D (RpSP-D) that has similar...

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Identifiers

PMID: 21489996
DOI: 10.1074/jbc.M111.224469
PMCID: PMC3121484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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