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Article

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations.

Biochemistry - 5 Jul 2016

Goh Boon Chong, Wu Huixing, Rynkiewicz Michael J, Schulten Klaus, Seaton Barbara A, McCormack Francis X

Abstract excerpt

Surfactant protein A (SP-A) is a collagenous C-type lectin (collectin) that is critical for pulmonary defense against inhaled microorganisms. Bifunctional avidity of SP-A for pathogen-associated molecular patterns (PAMPs) such as lipid A and for dipalmitoylphosphatidylcholine (DPPC), the major component of surfactant membranes lining the air-liquid interface of the lung, ensures that the protein is poised for...

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Identifiers

PMID: 27324153
DOI: 10.1021/acs.biochem.6b00048
PMCID: PMC5663190

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