Article
Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide.
Biochemistry - 18 Jul 2006
Ohya Madoka, Nishitani Chiaki, Sano Hitomi, Yamada Chieko, Mitsuzawa Hiroaki, Shimizu Takeyuki, Saito Tsuyoshi, Smith Kelly, Crouch Erika, Kuroki Yoshio
Abstract excerpt
Pulmonary surfactant protein D (SP-D), a member of the collectin group of innate immune proteins, plays important roles in lipopolysaccharide (LPS) recognition. We have previously shown that surfactant protein A (SP-A), a homologous collectin, interacts with Toll-like receptor (TLR) 2, resulting in alteration of TLR2-mediated signaling. In this study, we found that natural and recombinant SP-Ds exhibited specific...
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