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Allelic diversity of the pharmacogene CYP2D6 in New Zealand Māori and Pacific peoples

13 Oct 2022

Abstract excerpt

The enzyme cytochrome P450 2D6 (CYP2D6) metabolises approximately 25% of commonly prescribed drugs, including analgesics, anti-hypertensives, and anti-depressants, among many others. Genetic variation in drug metabolising genes can alter how an individual responds to prescribed drugs, including predisposing to adverse drug reactions. The majority of research on the CYP2D6 gene has been carried out in European and...

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PMID: 36313436
DOI: 10.3389/fgene.2022.1016416

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