Article
The Duffy Antigen/Receptor for Chemokines (DARC) and prostate-cancer risk among Jamaican men.
Journal of immigrant and minority health - 1 Feb 2011
Elson Joshua K, Beebe-Dimmer Jennifer L, Morgenstern Hal, Chilkuri Mahdavi, Blanchard John, Lentsch Alex B
Abstract excerpt
As an evolutionary response to prevent malaria infection, most Africans do not express the Duffy Antigen/Receptor for Chemokines (DARC) on their red blood cells. Results from experimental studies suggest that DARC expression inhibits prostate-tumor growth. We tested the hypothesis that men of African descent who lack DARC expression are at increased risk of prostate cancer. A case-control study involving 81...
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