Article

Inclusion of maintenance energy improves the intracellular flux predictions of CHO

2020-12-22

Abstract excerpt

Chinese hamster ovary (CHO) cells are the leading platform for the production of biopharmaceuticals with human-like glycosylation. The standard practice for cell line generation relies on trial and error approaches such as adaptive evolution and high-throughput screening, which typically take several months. Metabolic modeling could aid in designing better producer cell lines and thus shorten development times. Th...

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Literature Corpus work: 03f0bde5-5655-57b3-9781-f58e0c69eebf
DOI: 10.1101/2020.12.21.423738

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