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Article

Structural effects of oncogenic PI3Kα mutations.

Current topics in microbiology and immunology - 1 Jan 2010

Gabelli Sandra B, Huang Chuan-Hsiang, Mandelker Diana, Schmidt-Kittler Oleg, Vogelstein Bert, Amzel L Mario

Abstract excerpt

Physiological activation of PI3Kα is brought about by the release of the inhibition by p85 when the nSH2 binds the phosphorylated tyrosine of activated receptors or their substrates. Oncogenic mutations of PI3Kα result in a constitutively activated enzyme that triggers downstream pathways that increase tumor aggressiveness and survival. Structural information suggests that some mutations also activate the enzyme...

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Identifiers

PMID: 20593314
DOI: 10.1007/82_2010_53
PMCID: PMC3172713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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